In 1977, the administration and supervision of John Bosco was formally turned over to the De La Salle Brothers in the Philippines. The school was then appointed a Brother-Supervisor, Br. Thomas Cannon FSC and Artemio Noronio Manchup as the first school director. In 1983, John Bosco, and the Jose M. Soriano Learning Center, a La Salle-Supervised school in Coleto, also in Bislig, that was established in 1974, were merged. The Learning Center was then phased-out and all of its operations were transferred to John Bosco.

In 1997, pre-school, nursery, and kinder levels were opened at John Bosco. It was also in the same year that John Bosco School became John Bosco College with the opening of its College of Education.
In 1999, the JBC was accredited by the La Salle Schools Supervision Office and in 2006, the school was officially accepted as a District School of De La Salle Philippines.

The acceptance ceremony was done on February 2007 making it as the 18th district school of the De La Salle Philippines thus renaming it now as DE LA SALLE JOHN BOSCO COLLEGE.